Author's response to reviews Title: Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of Mitochondrial Membrane Potential Authors:

(Times New Roman 16) changed to Abstract (Arial 16) Background: (Times New Roman 12) changed to Background: (Arial 11) Line 6: In the present study, we have for the first time analyzed the mechanism of antineoplastic activity of cinnamon on cervical cancer cell line SiHa. Changed to: In the present study, we have reported the anti-neoplastic activity of cinnamon in cervical cancer cell line, SiHa. Methods: (Times New Roman 12) changed to Methods: (Arial 11) Line 10: The aqueous extract of cinnamon (ACE-c) was analyzed for cinnamaldehyde... Changed to: The aqueous cinnamon extract (ACE-c) was analyzed for its cinnamaldehyde... Line 11: HPTLC analysis and the polyphenol content was measured by... Changed to: HPTLC analysis. The polyphenol content of ACE-c was measured by... Line 12: We studied the effect of cinnamon on growth kinetics by performing growth curve, colony formation and soft agar assay. The samples exposed to ACE-c were analyzed.... Changed to: We studied the effect of cinnamon on growth kinetics by performing growth curve, colony formation and soft agar assays. The cells treated with ACE-c were analyzed .... Line 15: mRNA level by RT-PCR and at protein level by zymography. Changed to: mRNA and protein level by RT-PCR and zymography, respectively. Line 16: Her-2 protein expression was also checked in the control and treated samples by western blotting as well as confocal microscopy. Apoptosis studies and calcium signaling assays were analyzed by FACS analysis. Loss of mitochondrial membrane potential (∆ψm) in cinnamon treated cells was studied by JC-1 staining and analyzed by confocal microscopy as well as FACS analysis. Changed to: Her-2 protein expression was analyzed in the control and ACE-c treated samples by immunoblotting as well as confocal microscopy. Apoptosis studies and calcium signaling assays were analyzed by FACS. Loss of mitochondrial membrane potential (∆ψm) in cinnamon treated cells was studied by JC-1 staining and analyzed by confocal microscopy as well as FACS. Results: (Times New Roman 12) changed to Results: (Arial 11) Line 25: to down regulation of MMP-2 expression. Changed to: to downregulation of MMP-2 expression. Line 27: intracellular calcium signaling resulting into loss of mitochondrial membrane potential. Changed to: intracellular calcium signaling as well as loss of mitochondrial. Conclusion: (Times New Roman 12) changed to Conclusion: (Arial 11) Line 25: drug in cervical cancer cells. Changed to: drug in cervical cancer.